Life science and biotechnology has undoubtedly become one of the world's most rapidly developing fields of science and technology, and has made a series of breakthroughs, the biological reagent industry is in the upstream of the life science research industry chain, the development is particularly rapid, biological reagents refer to biological materials or organic compounds related to life science research, as well as clinical diagnosis, medical research reagents. As biological products consist of proteins, fats, sugars and nucleic acids, they must be prevented from inactivation during transportation and preservation. They can be divided into three categories according to the difference of usage: molecular reagents (enzymes, nucleic acids, carriers, etc.), protein reagents (recombinant proteins, antibodies, etc.) and cellular reagents (transfection reagents, culture media, etc.). As the core consumables in life science research, biological reagents are widely used in basic science research, high-throughput sequencing, in vitro diagnostics, pharmaceutical and vaccine development, and animal quarantine.

Challenge

The transportation and storage conditions of biological reagents are very strict. Since biological products consist of proteins, fats, sugars and nucleic acids, they must be prevented from deactivation during transportation and storage. If cargo damage occurs, the loss of assets is huge, and many antibody class reagents and enzyme class reagents are expensive and can reach thousands of dollars/mg (i.e. hundreds and tens of millions of dollars per kilogram), and the loss is often generated by batch type, which has to be cautious. As the life sciences research is subdivided into many directions, the research object is very complex, accordingly, the need to use a wide range of biological reagents. In terms of broad categories, molecular reagents mainly include nucleic acids and enzymes, protein reagents mainly include antibodies, antigens and recombinant proteins, cellular reagents mainly include culture media and transfection reagents, etc.. In fact, the storage temperature and humidity conditions for different biological reagents are different. Storage conditions generally require a low temperature and 35% to -75% humidity environment. According to the types of biological reagents to be transported, for some enzymes and other protein products, dry ice is required for transportation, while wet ice is sufficient for most other biochemical reagents. Dry ice or solid carbon dioxide, the temperature is -78℃, wet ice is the temperature of ice, generally for the freezing condition, such as the temperature of ice frozen at -20℃. Usually ice is used for transportation instead of crushed ice; crushed ice has a high temperature, while ice has a lower temperature; ice can maintain low temperature for a longer time; crushed ice can easily turn into water. In biological reagent storage, biological reagent cold storage as well as biological reagent storage refrigerators are used in large quantities, with many refrigerators and cumbersome management, such as abnormalities in temperature and humidity, which are not handled in time and have the risk of inactivation.

Solution

GSP is the quality management specification for drug business and GMP is the quality management specification for drug production. Humpback Whale strictly abides by the relevant regulations and standards of the State Drug Administration when assisting customers to establish biological reagent transportation and storage programs. The LoRa program automatically measures and controls the temperature of biological reagent cold storage and all kinds of biological reagent refrigerators, cryogenic refrigerators, cryogenic liquid nitrogen storage tanks through temperature and humidity probes, and realizes 24-hour uninterrupted detection, alarm, recording and data storage and query of the temperature of refrigerators through LoRa technology. The gateway in LoRa program covers a wide range, and the gateway has a display screen, so that the real-time temperature of the temperature probe under its jurisdiction can be seen at a glance, and the management personnel can also check the temperature history and status of the responsible area through the network or cell phone; finally, it can achieve the centralized control of each temperature and humidity monitoring area. Finally, it achieves centralized control of temperature and humidity monitoring areas, realizes real-time online supervision of temperature of biological reagents, minimizes the impact of problems arising from abnormal temperature and humidity, and nips the risk in the bud. The main equipment used in this program includes LoRa gateway with screen, built-in temperature and humidity probe, external temperature and humidity probe, ultra-low temperature probe, etc.